APLAUD

Anti Platelet Useful Dose Trial. A dose-finding phase II trial assessing the safety and pharmacokinetics of 4 doses of lotrafiban vs placebo + aspirin for 2º prevention in patients with cerebrovascular or cardiovascular disease
Conclusion The high-dose arm was ended early due to cases of excessive bleeding; the phase III study (BRAVO) was terminated in December 2000 due to lack of efficacy and safety concerns
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