BIRC5

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BIRC5

A gene on chromosome 17q25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. Gene expression is high during foetal development and in most tumours, yet low in adult tissues.

Function
BRIC5 is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation, and is required for chromatin-induced microtubule stabilisation and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. BRIC5 may play a role in neoplasia, counteract default induction of apoptosis in G2/M phase and inhibit caspase-3 and caspase-7.
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and API2 cif ARA, API4 fob Richards Bay, API5 fob Newcastle, API8 CFR South China, Indonesian Coal and Australian Coking Coal, which serve growing markets in Asia and Europe.
by the fall in the index linked, API4 benchmark coal price, for export
The index linked API4 benchmark coal price for coal from Richards Bay
fall in the export API4 benchmark coal price was slightly offset in
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00/GJ, 6 000kcal API4 coal price of US$90/t and a 30% discount in pricing to API4 for the 5 000kcal Export product
the beginning of 2009, the API4 price had fallen to US$75.