APEX1

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APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.
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They found that by blocking a cell repair enzyme called APE1 with special molecules, they had developed stopped two repair routes at once.
This study provides the first evidence that APE1 is an important new target," the Daily Express quoted Srinivasan Madhusudan, the lead researcher as saying.
Implications of XRCC1, XPD and APE1 gene polymorphism in North Indian population: a comparative approach in different ethnic groups worldwide.
Animal studies have shown that heterozygous (reduced-function) APE1 mice, which maintain 500,4 Ape1 repair activity, exhibit increased risk for phenotypic consequences associated with oxidative stress, most notably reduced survival and elevated cancer susceptibility (Meira et al.
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination.
We have genotyped polymorphic DNA repair genes preferentially involved with base excision repair (BER) and nucleotide excision repair (NER) activities (XRCC1, XRCC3, APE1, XPD) corresponding to the repair of X-ray- and UV light-induced DNA damage, respectively.
Conversely, the XRCC1, XRCC3, and APE1 variant genotypes are associated with increased aberrations in most categories.
The variant genotypes for XRCC1, XRCC3, and APE1 are associated with increased CA in the most observed category (Table 3).
We found that variant gene alleles for BER (XRCC1 194Trp, XRCC/399Gln, XRCC3 241 Met, and APE1 148Glu) but not those for NER (XPD 312Asn and XPD 751Gln) are consistently associated with defective repair of X-ray-induced DNA damage.
1] Antigen recognition Lys69Glu protein XPD (ERCC2) Nucleotide excision Lys751Gln repair (NER) enzyme system XPF NER multiple SNPs XRCC1 Base excision repair Arg399Gln APE1 Apurinic/apyrimidinic Asp148Glu endonuclease 1 ALAD [delta]-Aminolevulinic G177C acid dehydratase TLR4 Type I transmembrane A896G protein D299G TNF-[alpha] Cytokine G-308A 1999 Gene Effect of polymorphism References CYP1A1 Unknown Spurr et al.
1] TLR4 (endotoxin) Hay dust TNF-[alpha] production in TNF[alpha] hypersensitivity pneumonitis Ozone Influx of inflammatory TLR4 cells in the lung Airborne PAHs PAH metabolites in urine, CYP1A1 DNA adducts, or GSTM1 measures of NAT2 genotoxicity GSTP1 EPHX1 Lung cancer GSTM1 Nitro-PAHs Genotoxic effects in NAT2 respiratory tract Ultraviolet light Basal cell carcinoma XPD Ionizing radiation DNA damage in lymphocytes XPD XPF XRCC1 Prolonged cell cycle APE1 delay Tobacco smoke Lung cancer CYP1A1 GSTM1 NAT1 NAT2 EPHX1 XRCC1 Bladder cancer CYP1A2 NAT2 GSTM1 Bronchogenic carcinoma AHR Emphysema and chronic EPHX1 obstructive pulmonary GSTM1 disease Environmental Lung cancer GSTM1 tobacco smoke Exposure Rating (a) Reference Arsenic 3 Chiou et al.