APC resistance


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Activated Protein C Resistance

An inherited (autosomal dominant) or acquired defect in the anticoagulant response to activated protein C, resulting in an increased risk of thrombosis.
Clinical findings Increased risk of deep vein thrombosis (DVT), venous thrombosis; it is responsible for 20% to 50% of DVT.
Pathogenesis Protein C, a key regulator of coagulation, circulates in an inactivated form and is activated by the binding of thrombin to thrombomodulin receptors on vascular endothelial cells; once activated, protein C lyses coagulation factors Va and VIIIa. Activated protein C resistance is caused by a failure of protein C to cleave Factor Va and/or Factor VIIIa.

APC resistance

Activated protein C resistance, see there.

APC resistance

Abbrev. for activated protein C resistance, an abnormal tendency to blood clotting caused by a mutation in the gene for blood clotting factor V. This mutation is known as the FACTOR V LEIDEN MUTATION. APC resistance is the commonest cause of inherited THROMBOPHILIA.
References in periodicals archive ?
All assessments were reported to be within normal physiological limits except for the APC resistance assay, which was reported low at 0.
Our excellent HemosIL and Chromogenix reagent product line offers a broad spectrum of diagnostic tests, including assays for the detection of APC resistance and factor V Leiden mutations.
When testing for factor V Leiden, a screening test is done to determine APC resistance.
This finding is in agreement with the fact that patients with the FV-Leiden mutation show APC resistance.
Eighteen patients consented to a prospective hypercoagulability evaluation that included assays for protein C, protein S, APC resistance, factor V Leiden mutation, anticardiolipin antibodies, antineutrophil cytoplasmic antibodies (ANCA), rheumatoid factor, antithrombin III, anti-smooth muscle antibody, and lupus anticoagulant panel.
Sensitivity and specificity of the APC resistance assay in detection of individuals with factor V Leiden.
APC Resistance (functional test for Factor V Leiden)
The technology provides data in concordance with the existing method of detecting APC resistance, known as the Activated Partial Thromboplastin Time (APTT) assay.
24) reported that the presence of LA was significantly associated with acquired APC resistance (APC-R) in patients with SLE.
APC resistance is characterized by a poor anticoagulant response to APC, which is activated by thrombin and inhibits coagulation by cleaving and inactivating coagulation factors Va and VIIIa.
Approximately 95% of individuals with functional APC resistance have the FVL mutation, which can be detected by a polymerase chain reaction amplification of a 223-base pair (bp) fragment after MnlI cleavage, (21) but newer assays by invader probe, Third Wave technology, and Light Cycler technology have also been developed (Figure 5).
The novel technology provides data in concordance with the existing method of detecting APC resistance, known as the Activated Partial Thromboplastin Time (APTT) assay.