AP2M1

AP2M1

A gene on chromosome 3q28 that encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. AP2M1 is required for the activity of a vacuolar ATPase, which is responsible for proton pumping needed to acidify endosomes and lysosomes. It may also play a role in regulating the intracellular trafficking and function of CTLA-4 protein.
References in periodicals archive ?
The validated target genes for miR-224 are AP15 (apoptosis inhibitor 5) (21), AP2M1 (adaptor-related protein complex 2, mu 1 subunit) (33), CDC42 [cell division cycle 42 (GTP binding protein, 25 kDa)], CXCR4 [chemokine (C-X-C motif) receptor 4] (30), SMAD4 (SMAD family member 4) (34), SMAD5 (SMAD family member 5) (17), SLMAP (sarcolemma-associated protein) (17), H3.
4] Human genes: MIR, microRNA gene family; API5, apoptosis inhibitor 5; AP2M1, adaptor-related protein complex 2, mu 1 subunit; CDC42, cell division cycle 42 (GTP binding protein, 25 kDa); CXCR4, chemokine (C-X-C motif) receptor 4; SMAD4, SMAD family member 4; SMAD5, SMAD family member 5; SLMAP, sarcolemma-associated protein; H3.