AP1S2

AP1S2

A gene on chromosome 7q22.1 that encodes a subunit of the trans-Golgi network clathrin-associated protein complex AP-1, which is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. The vesicles are involved in endocytosis and Golgi processing; the AP complexes recruit clathrin to membranes and recognise sorting signals within the cytosolic tails of transmembrane cargo molecules.
References in periodicals archive ?
The positive outcome of the screen was the identification of 9 X-linked ID/MR genes: AP1S2 (adaptor-related protein complex 1, sigma 2 subunit), CUL4B (cullin 4B), BRWD3 (bromodomain and WD repeat domain containing 3), UPF3B [UPF3 regulator of nonsense transcripts homolog B (yeast)], ZDHHC9 (zinc finger, DHHC-type containing 9), SLC9A6 [solute carrier family 9 (sodium/hydrogen exchanger), member 6], SYP (synaptophysin), ZNF711 (zinc finger protein711), and CASK [calcium/calmodulin-dependent serine protein kinase (MAGUK family)].
7] Human genes: FMR1, fragile X mental retardation 1; AP1S2, adaptor-related protein complex 1, sigma 2 subunit; CUL4B, cullin 4B; BRWD3, bromodomain and WD repeat domain containing 3; UPF3B, UPF3 regulator of nonsense transcripts homolog B (yeast); ZDHHC9, zinc finger, DHHC-type containing 9; SLC9A6, solute carrier family 9 (sodium/hydrogen exchanger), member 6; SYP, synaptophysin; ZNF711, zinc finger protein 711; CASK, calcium/calmodulin-dependent serine protein kinase (MAGUK family).