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AP endonuclease

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AP endonuclease


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A similar inhibition pattern was observed with the homologous Eseheriehia coil protein, exonuclease III, but no inhibition was seen with the structurally distinct AP endonuclease E.
Inhibition of AP endonuclease by lucanthone leads to the accumulation of abasic sites in DNA that are converted to lethal double-strand breaks leading to sensitization of tumor cells to alkylating agents and to radiation.
For example, the following DNA repair genes were altered after arsenic treatment: Xeroderma pigmentosum group D-complementing protein (XPD, DNA excision repair protein ERCC2), Xeroderma pigmentosum group C-complementing protein (XPC-), AP endonuclease 1 (APE1), DNA ligase-1 (DNL1), DNA polymerase delta catalytic subunit (DPD), DNA topoisomerase II alpha (TOP2A), DNA damage-inducible protein GADD45 (Chen et al.
 
 
 
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