ANGPT1

ANGPT1

A gene on chromosome 8q23.1 that encodes angiopoietin 1, a secreted glycoprotein which, like other angiopoietins, binds to endothelial cell-specific tyrosine-protein kinase receptor. It plays a key role in mediating interactions between the endothelium and surrounding matrix and mesenchyme, andit  inhibits endothelial permeability. Angiopoietin 1 plays a role in regulating angiogenesis; endothelial cell survival, proliferation, migration, adhesion and spreading; reorganisation of the actin cytoskeleton; and maintains vascular quiescence. It contributes to blood vessel maturation and stability and may be involved in cardiac embryogenesis.
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The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
Upregulation of angiogenesis factors such as VEGF-A and ANGPT1 was responsible for the increase in capillary density.
This effect on endothelial cells is most intense during SC differentiation, while myogenin is being expressed, in parallel to an increase in factors, such as VEGF and ANGPT1 [7, 8].
In agreement with increased myogenin mRNA expression in Pre, which is expressed while proangiogenic effects of differentiating SCs are most intense, expression of VEGF-A, ANGPT1, FGF-2, and HGF (which are known to be produced by SCs) increased.
ANGPT1, TIE2, PDGFR-B, CDH5, S1PR1, FGF2, Shh, and TGFRB1), and blood vessel maturation/formation factor (e.
The underlying mechanism is likely that CF whole extract up-regulated expression of certain genes for angiogenesis and associated growth factors and receptors, including IGF1, CTGF, NRP2, VEGFR3, HIF1A, MMP2, MMP9, TIMP2, PLG, PLAU, ITGAV, 1TGB3, beta-catenin, PECAM1, ANGPT1, TIE-2, PDGFRB, CDH5, S1PR1, FGF2, Shh, TGFRB1, and Ephrin B2.
The best-characterized ligands are ANGPT1 and ANGFT2 (Gale and Yancopoulos 1999; Thomas and Augustin 2009).
ANGPT1 and ANGPT2 are specific ligands of TIE2 with similar affinity.