AMPA receptor


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AMPA re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission and also binds α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and acts as a cation channel.

AMPA receptor

A member of the ionotropic class of glutamate receptors (which includes NMDA and kainate receptors).

Functions
Mediate fast excitatory synaptic transmission in the CNS; play a key role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD).

Structure
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit composition determines the physiological properties of AMPA receptors: those with a GluR2 subunit have low permeability to Ca2+; those lacking a GluR2 subunit have high Ca2+ permeability.

AMPA receptor

Neurophysiology Any of a family of distinct ionotropic glutamate–excitatory post-synaptic receptors widely expressed in the CNS, which are the 1º memory receptors. See Excitatory amino acid receptor channel, Glutamate receptor.
References in periodicals archive ?
announced today that the latest data on its in-house developed AMPA receptor antagonist Fycompa (perampanel hydrate, perampanel) will be presented at the 69th American Epilepsy Society (AES) Annual Meeting to be held from December 4 to 8 in Philadelphia in the United States.
Because these receptors are so similar in structure, it was assumed that they function in much the same way, but when we altered the dimer interface, the site where two subunits come together within each pair, we found that the NMDA receptor works just the opposite of the way that the AMPA receptor works," points out Popescu.
Researchers have found increases, decreases, and no change in NMDA and/or AMPA receptor subunit levels (for examples see Dettmer et al.
A sampling of topics: neurochemical and developmental aspects of glutamate receptors in the retina, insights from structure-function studies of AMPA receptor agonists and competitive antagonists, NMDA receptor-mediated activation of arachidonic acid and nitric oxide signaling pathways in the spinal processing of pain, AMPA receptor-mediated neuronal death in motor neuron disease, excitotoxicity and white matter damage, and chemoreception of umami in caterpillars.
These target the function of a molecule in the brain called the AMPA receptor, thought to help us form memories.
Here, we questioned whether glutamate acts selectively at NMDA receptors to elicit feeding or whether it also acts at the AMPA receptor subtype.
207) It is feasible that the infusion of antisense oligonucleotides targeted to certain genes in a cell-death signal pathway might also be effective in vivo because infused antisense oligonucleotides targeted to the GluR2 AMPA receptor have been shown to modify synaptic excitatory transmission in the cochleae of guinea pigs.
In animal models, neuroprotective agents, known as glutamate antagonists, minimize brain cell death by inhibiting glutamate release, or blocking glutamate binding at NMDA or AMPA receptor sites.
Cortex Pharmaceuticals has developed a class of compounds called AMPA receptor modulators, which enhance the glutamate-based transmission between brain cells.
A PHASE I TRIAL OF BRIEF INTRAVENOUS INFUSION OF THE AMPA RECEPTOR BLOCKER LY293558 TO EXAMINE SAFETY AND EFFECTS OF PAIN PERCEPTION IN NORMAL VOLUNTEERS.
In New Zealand, the patent office has given Cortex a notice of allowance for a patent entitled, "Benzofurazan Compounds which Enhance AMPA Receptor Activity.
CX1739, an AMPA receptor positive allosteric modulator (AMPA PAM), is a Phase 2 oral drug product.