RUNX1

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RUNX1

A gene on chromosome 21q22.3 that encodes the alpha subunit of core binding factor (CBF), a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is thought to be involved in the development of normal haematopoiesis. 

Molecular pathology
Chromosomal translocations involving RUNX1 are well documented and associated with several types of leukaemia.
References in periodicals archive ?
NSA has provided a summary of the changes: You must swap from the old AML1 form to the new ARAMS form and send it to SouthWestern instead of your local authority.
This will be very similar to the current AML1 document with a few minor changes.
Apart from chromosome 5, ETV6 has also been found to fuse with other genes in different chromosomes like AML1 in acute lymphoblastic leukemia (ALL), with ABL or JAK2 in early pre-B-cell ALL, with MN1 in MPD, with MDS1/EVI1 in MPD, and with STL in a B-cell ALL cell line [7].
A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia.
Recently, Fontana et al (7) have shown the inhibitory role of miRNA 17-5P-20a-106a in monocytopoiesis through targeting AML1 (Figure 3), a subunit of core binding factor, leading to downregulation of macrophage colony-stimulating factor receptor.
Mutations of AML1 in non-M0 acute myeloid leukemia: six novel mutations and a high incidence of cooperative events in a South-east Asian population.
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.