AMACR


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AMACR

Alpha-Methylacyl coenzyme A racemase. An enzyme involved in beta-oxidation of branched-chain fatty acids, the gene for which is overexpressed in certain cancers, in particular prostate.

AMACR

alpha-Methylacyl-CoA racemase.
References in periodicals archive ?
In conclusion, key morphologic clues and a focused immunohistochemical panel, including CK7, AMACR, TFE3, cathepsin K, and CAIX, now allow most resected RCCs with papillary architecture and clear cells to be accurately classified.
52,104) The immunoprofile of MTSCC is similar to that of papillary RCC and is positive for vimentin, AE1/AE3 keratins, CK7, AMACR, and RCC marker.
A recent study (18) of clear cell adenocarcinomas involving the urinary bladder and urethra, including a subset of clear cell adenocarcinomas that resembles NA, has shown that immunohistochemistry with p63, high-molecular-weight cytokeratin, and AMACR has limited utility in distinguishing NA-like clear cell adenocarcinoma from NA.
The usual phenotype of translocation carcinoma (CK7 -, AMACR +, CD10 +, EMA -) helps separate these from conventional clear cell renal carcinoma (CK7 -, AMACR-, CD10 +, EMA +) and papillary renal cell carcinoma (CK7 +, AMACR +, CD10 +, EMA+) (9,10).
The study also found a novel genetic variant in AMACR that is present in the general population, and which may influence the course of how colon cancer may progress.
Moreover, the positivity for AMACR is not observed in all PAA cases and can be seen in other types of carcinomas.
In general, basal cell hyperplasia is diffusely positive for both p63 and HMWCK and negative for AMACR and B-cell lymphoma 2 (Bcl-2) (10-12) (Figure 2, B).
The researchers analyzed the AMACR gene's abnormal expression patterns using a sophisticated laser-capture microdissection technique to identify the key biological events that lead to colon cancer progression.
Gene Localization annotation prediction SwissProt localization Tissue specificity KLK3 (PSA) Secreted Secreted protein Primarily prostate ACPP Secreted No annotation Primarily prostate VEGF Secreted Secreted protein Ubiquitous FN1 Secreted Secreted protein Ubiquitous ZWINT Not secreted Nucleus Moderatea AMACR Not secreted Peroxisome mitochondrion Ubiquitous HPN Not secreted Type II membrane Moderatea We analyzed 7 genes by the secretion and specificity prediction methods described above.
He and his collaborators have characterized a number of biomarkers of prostate cancer including AMACR, EZH2 and hepsin.
The AMACR gene product of AMACR is overexpressed in prostate cancer using complementary DNA (cDNA) library subtraction combined with high-throughput microarray screening and, in recent years, has been used as a positive marker for prostate cancer.
The papillary area was positive for CK7, AMACR and vimentin, but negative for CD117 and E-cadherin (Fig.