amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1

(redirected from ALS-PDC1)

amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1

A neurodegenerative disorder (OMIM:105500) characterised by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.

Molecular pathology
Defects of TRPM7 have been linked to amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.