ALK


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ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
References in periodicals archive ?
Insight ALK Screen is inexpensive, highly sensitive and well suited to handle larger numbers of specimens than the ALK detection methods currently available.
GenASIs further adds the ability to perform “walk away” automated genetic tissue scanning for ALK using an 81 slide continues scanning robot.
The oral agent has inhibitory activity against several kinases, including ALK L1 196M and ALK C1156Y, two point mutations identified in patients resistant to the reigning ALK inhibitor crizotinib, Dr.
Break-apart FISH involves labeling the areas that flank the ALK gene with red and green fluorescent probes.
The study assessed crizotinib in 76 patients with NSCLC and ALK gene fusion.
The success of the VENTANA ALK (D5F3) CDx Assay is an excellent example of Roche's continued commitment to advancing the standard of care for patients," says Dan Zabrowski, President of Roche Tissue Diagnostics (Ventana).
The ALK rearrangements are associated with adenocarcinoma cell type, which is a diagnosis that is made by the surgical pathologist and is currently a basis for sending tissue for ALK testing.
LDK378, developed by Novartis, targets ALK - a key cancer gene in a subset of lung cancer, lymphoma and the childhood cancer neuroblastoma, and may be associated with other cancers, including breast and colorectal cancer.
Of the six families with at least three cases of the disease, four had an extra copy of the mutation on the ALK gene.
Pfizer's XALKORI([R]) (crizotinib) is approved in the US for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with ALK fusions as detected by an FDA-approved test.
Ventana), a member of the Roche Group, today announced its FDA submission for premarket approval (PMA) of the VENTANA ALK (D5F3) CDx Assay.