angiolymphoid hyperplasia with eosinophilia

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an·gi·o·lym·phoid hy·per·pla·si·a with e·o·sin·o·phil·i·a

solitary or multiple small benign cutaneous erythematous nodules, occurring mainly on the head and neck in young adults, characterized by dermal proliferation of blood vessels with vacuolated histiocytoid endothelial cells and with a varied infiltrate of eosinophils, lymphocytes which may form follicles, and histiocytes.
Synonym(s): Kimura disease

angiolymphoid hyperplasia with eosinophilia

An uncommon idiopathic condition with some features of Kimura disease, which presents in adults as one or more red-blue papules, plaques, or nodules in the head and neck, less commonly in the hands, shoulders, and elsewhere. It is unknown whether it is neoplastic or reactive.
Prognosis ALHE is clinically benign but persistent and treatment is refractory.


Tetsuji, 20th century Japanese pathologist.
Kimura disease - solitary or multiple small benign cutaneous erythematous nodules. Synonym(s): angiolymphoid hyperplasia with eosinophilia
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References in periodicals archive ?
She underwent punch biopsy of two of the nodules, and histologic examination confirmed the initial diagnosis of ALHE.
ALHE is a benign, locally proliferating lesion, which usually affects middle-aged Caucasian women and tends to have a predilection for the periauricular area and scalp (1).
With regard to the histologic differences, ALHE is characterized by thick-walled vessels secondary to proliferation of "histiocytoid" endothelial cells, which are plump cells with large nuclei and abundant eosinophilic cytoplasm.
The transoral punch biopsy revealed vascular proliferation with eosinophilia, which was suggestive of both Kimura's disease and ALHE.