ALDH1A1

ALDH1A1

A gene on chromosome 9q21.13 that encodes a cytosolic aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation. The ALDH1A1 gene may be involved in regulating the metabolic responses to a high-fat diet.
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The ALDH1A1 enzyme is found in the cytosol, whereas both ALDH1B1 and ALDH2 are produced in the nucleus but have leader sequences that direct them to cell components called mitochondria, where they exert their functions in the mitochondrial interior (i.
It is likely that the ALDH1A1 and ALDH1B1 enzymes significantly contribute to acetaldehyde metabolism only in situations where ALDH2 is inactivated, either pharmacologically or because of the presence of the ALDH2*2 allele.
Our image analysis along with in-depth spot analysis (lower panel of Figure 4A, B and C) revealed omental depot with higher expressions of ANXA 6, HSPB1, TAGLN, ALDH1A1 and CALD 1, whereas in the subcutaneous depot, expressions of PRDX 6 and GSN were found to be high.
There is also a study reporting the increased levels of ALDH1A1 in omental fat (Perez-Perez et al.
The PB1 crystallin was found higher expression in CCA patients and in ALDH1A1 no significant differences was noticed.
the cytosol) and is encoded by the ALDH1A1 gene, and ALDH2, which is found in the mitochondria and is encoded by the ALDH2 gene.
Several promoter polymorphisms in the ALDH1A1 gene affect gene expression in vitro (Spence et al.
1) Spence and colleagues (2003), who studied people with a variety of ethnic backgrounds, recently identified polymorphisms of the ALDH1A1 gene resulting in three gene variants (i.
These findings in Southwest California Indians also are consistent with the idea that the ALDH1A1 gene may influence alcohol consumption and smoking in a manner similar to what has been reported for the less active ALDH2*2 variant.
ALDH1, which is encoded by the ALDH1A1 gene, has been associated with alcoholism, alcohol-induced flushing, and alcohol sensitivity (Chan 1986; Yoshida 1992).
Among Afro-Trinidadians, however, the small number of subjects with atypical ALDH1A1 polymorphisms limited any conclusions on the possible impact on alcoholism in that population (Moore et al.