ALDH3A2

(redirected from ALDH10)

ALDH3A2

A gene on chromosome 17p11.2 that encodes an aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation. The ALDH3A2 gene product catalyses the oxidation of long-chain aliphatic aldehydes to fatty acid.

Molecular pathology
ALDH3A2 mutation causes Sjögren-Larsson syndrome.
References in periodicals archive ?
Twelve ALDH genes (ALDH1 through ALDH10, SSDH, and MMSDH) have been identified in humans.
This assay was both sensitive and reliable for the diagnosis of SLS patients, which is of interest because the assays described previously in the literature have several drawbacks, including the use of noncommercially available or radioactive substrates and high residual activities in patients who were expected to be completely deficient because of nonsense mutations in the ALDH10 gene (3,10).
When we assessed FALDH activity by measuring production of NADH fluorometrically (3), we observed high residual background activity in fibroblasts derived from SLS patients with nonsense mutations in ALDH10.