anaplastic large cell lymphoma

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Related to ALCL: ACL

an·a·plas·tic large cell lym·pho·ma

a form of lymphoma characterized by anaplasia of cells, sinusoidal growth, and immunoreactivity with CD30 (Ki-1 or Ber-H2).
Synonym(s): Ki-1+ lymphoma

anaplastic large cell lymphoma

A primary non-B cell non-Hodgkin lymphoma, usually of T cell lineage, which is immunoreactive for CD30 and often ALK (anaplastic lymphoma kinase) and characterised by scattered to abundant “hallmark cells”—medium-sized cells with abundant cytoplasm and kidney-shaped nucleus, which tend to aggregate around blood vessels. ALCLs arise either as a primary neoplasm in a node or lymphoid tissue, soft tissue, lung, or skin, or secondary to the transformation of a lymphoproliferative disorder (e.g., mycosis fungoides), T-cell lymphoma, lymphomatoid papulosis or Hodgkin lymphoma.
DiffDx Classical Hodgkin lymphoma.
Clinical findings Often a late-presenting lymphoma with “B symptoms” including night sweating and weight loss.
Molecular >90% have rearrangement of T cell receptor, chromosomal translocation involving the nucleophosmin gene on chromosome 5.
Management CHOP, radiation for bulky disease.

anaplastic large cell lymphoma

Abbreviation: ALCL
A rare form of non-Hodgkin, T-cell lymphoma that may behave indolently when limited to the skin or may be more aggressive and spread to lymph nodes throughout the body.
See also: lymphoma
References in periodicals archive ?
SR-786 NPM/ALK positive human ALCL (anaplastic large cell lymphoma) cells were from DSMZ (Braunschweig, Germany), CD-417 NPM/ALK positive mouse ALCL cells were isolated from CD4-NPM/ALK mice, HL60 (human promyelocytic leukaemia cells) were obtained from ATCC (Manassas, VA, USA).
In Perez and colleagues' (2010) review, they found that only 11 of the 37 case reports of ALCL in HIV patients had another underlying AIDS-defining illness.
It has also asked healthcare professionals to report any confirmed cases of ALCL in patients with breast implants.
In the 29 ALCL cases, 14 presented with a seroma and 1 without a seroma; no data were reported for the remaining 14 cases.
33-37) ALK- ALCL tumors arising in the skin and gastrointestinal tract must be distinguished from C-ALCL and enteropathy-associated T-cell lymphoma.
As the name implies, the small cell variant of ALCL characteristically has numerous small- and medium-sized lymphocytes that are markedly irregular, often with a "cerebriform" appearance.
While the increased risk of ALCL with breast implants is low, the FDA* states the risk is higher for implant capsule median age of seven years.
Among all patients with breast lymphoma identified from January 1986 to the time of writing, 6 cases of ALCL involving the breast were identified.
Ancillary techniques are essential to establish a diagnosis of ALCL because other neoplasms, including classical Hodgkin lymphoma, a subset of large B-cell lymphomas, and other poorly differentiated tumors, histologically overlap with ALCL.
There are two distinct forms/types of ALCL, including primary cutaneous ALCL and systemic ALCL (sALCL).
Recently, it has been demonstrated that 25% to 60% of ALCL lymphomas carry the t(2;5)(p23;q35) translocation, (3) which results in the formation of a novel chimeric protein, nucleophosmin/anaplastic lymphoma kinase (ALK), believed to be involved in neoplastic transformation.
Recommended as Treatment for Relapsed or Refractory Hodgkin Lymphoma and Systemic ALCL