Nor did we find this association to be modified by polymorphisms in the ALAD
gene or by medication use.
Sanchez-Fructuoso et al (116) evaluated pathological changes as well as the response of ALAD
activity before and after calcium EDTA treatment in rats fed 500 ppm lead acetate for 90 days.
These Pb effects include increased urinary excretion of ALA, increased porphyrin formation and decreased ALAD
6 years), ALAD
genotype modified associations between lead dose and uric acid levels.
SNPs, this study is the first to address more than one SNP.
can be inhibited by a variety of chemicals, including lead, trichloroethylene, bromobenzene, and styrene (Fujita et al.
Desnick says this mutation, coding for ALAD
synthesis, may make that ALAD
enzyme--and hence, the porphyrin pathway--more sensitive to lead.
Apart from ALAD
, (G6PD), an thiol containing first enzyme of the pentose phosphate pathway, that provides extra mitochondrial NADPH to the cells through the oxidation of glucose-6-phosphate to 6-phosphogluconate, which in turn provide the NADPH to maintain constant levels of GSH to GR, mediates the conversion of GSSG to GSH.
The inhibition in erythrocyte ALAD
activity, a characteristic phenomenon in LP (19) observed in all the patients studied (Table 1) was not correlated with either urinary ALA (r = 0.
0 [micro]g/dL) found that the ALAD
polymorphism did not change the association between blood lead and hypertension at occupational exposure levels compared with ALAD
1 homozygous carriers (Lee et al.
Effect on ALAD
activity in isolated rat hepatocytes.
activity is present in great excess in the healthy liver, and a partial enzyme deficiency such as in heterozygous ALAD
deficiency is not accompanied by any clinical consequence (2).