ALAD


Also found in: Acronyms.

ALAD

δ-aminolevulinic acid dehydratase.
References in periodicals archive ?
Nor did we find this association to be modified by polymorphisms in the ALAD gene or by medication use.
Sanchez-Fructuoso et al (116) evaluated pathological changes as well as the response of ALAD activity before and after calcium EDTA treatment in rats fed 500 ppm lead acetate for 90 days.
These Pb effects include increased urinary excretion of ALA, increased porphyrin formation and decreased ALAD activity.
Although ALAD can be inhibited by a variety of chemicals, including lead, trichloroethylene, bromobenzene, and styrene (Fujita et al.
Desnick says this mutation, coding for ALAD synthesis, may make that ALAD enzyme--and hence, the porphyrin pathway--more sensitive to lead.
Apart from ALAD, (G6PD), an thiol containing first enzyme of the pentose phosphate pathway, that provides extra mitochondrial NADPH to the cells through the oxidation of glucose-6-phosphate to 6-phosphogluconate, which in turn provide the NADPH to maintain constant levels of GSH to GR, mediates the conversion of GSSG to GSH.
The inhibition in erythrocyte ALAD activity, a characteristic phenomenon in LP (19) observed in all the patients studied (Table 1) was not correlated with either urinary ALA (r = 0.
0 [micro]g/dL) found that the ALAD polymorphism did not change the association between blood lead and hypertension at occupational exposure levels compared with ALAD1 homozygous carriers (Lee et al.
Effect on ALAD activity in isolated rat hepatocytes.
ALAD activity is present in great excess in the healthy liver, and a partial enzyme deficiency such as in heterozygous ALAD deficiency is not accompanied by any clinical consequence (2).