AKT2

AKT2

A gene on chromosome 19q13.1, which encodes a protein of the subfamily serine/threonine kinases containing SH2 (Src homology 2)-like domains, and phosphorylates several known proteins.

Molecular pathology
The gene is amplified and overexpressed in some primary ovarian tumours and pancreatic ductal carcinomas.
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Within the AKT cascade, the response variable consisted of eight correlated gene expression values for each placenta--that is, two biopsies per placenta and four target genes (BDNF, AKT1, AKT2, and AKT3) measured in each biopsy.
0001) for the SOS cascade (BDNF, SOS1, SOS2, and SYN1), whereas for the AKT cascade (BDNF, AKT1, AKT2, and AKT3) associations between gene expression and [PM.
The binding of BDNF to its receptor TRKB initiates three main signaling cascades: pLc gamma cascade (PLCG1 and PLCG2), AKT cascade (AKT1, AKT2, and AKT3) and SOS cascade (SOS1, SOS2, and SYN1).
AKT2 acts as an interpreter for the hormone insulin.
Lead researcher Prof Stephen O'Rahilly told the BBC that cancer drugs were available which targeted AKT1 and which also act against AKT2.
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas.
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.
These compounds display nanomolar inhibitory activity and are >100-fold selective over AKT2, AKT3, and 96 other enzyme targets.
Three members, AKT1, AKT2, and AKT3, have been identified in this subfamily and VQD-002 has been shown to inhibit all three isoforms.
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.