AKAP5

AKAP5

A gene on chromosome 14q21-q24 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunit of protein kinase A (PKA), confining the enzyme to discrete locations within the cell. AKAP5 binds to the RII-beta regulatory subunit of PKA, as well as to protein kinase C and the phosphatase calcineurin. It is primarily expressed in the cerebral cortex, may anchor the PKA protein at postsynaptic densities (PSD) and be involved in regulating postsynaptic events; it is also expressed in T cells and may inhibit IL-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
References in periodicals archive ?
III] specific A kinase (PRKA) anchor AKAP5 Signal transduction protein 5 Ataxin 1 ATXN1 RNA binding CD22 antigen CD22 Cell adhesion Connective tissue CTGF Regulation of cell growth factor growth, cell adhesion RNA, U70 small nucleolar RNU70 Unknown Integrin beta 1 binding ITGB1BP1 Cell adhesion protein 1 E2F transcription E2F1 [G.