AKAP1

(redirected from AKAP149)

AKAP1

A gene on chromosome 17q21-q23 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds type-I and -II regulatory subunits of protein kinase A, anchoring them to the cytoplasmic face of the mitochondrial outer membrane. AKAP1 is thought to play a role in cAMP-dependent signal transduction and in directing RNA to a specific cellular compartment.
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However, at G1/S transition, phosphorylation of NE associated AKAP149 by PKA causes release of PP1 from the AKAP149 complex resulting in downregulation of PP1 activity towards assembled lamins (Fig.
As already explained, under normal conditions PP1 is targeted to NE by AKAP149 at the end of mitosis and it induces lamin B assembly.
AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase.