AKAP12

AKAP12

A gene on chromosome 6q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. AKAP12 is expressed in endothelial cells, fibroblasts and osteosarcoma cells, associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction.

Molecular pathology
AKAP12 antibodies may be produced in myasthenia gravis.
References in periodicals archive ?
Miano, associate director of the Aab Cardiovascular Research Institute at the University of Rochester Medical Center had identified a number of genes that were activated or turned on by retinoids, one of which was AKAP12.
Because research in the cancer field suggested it was a tumor suppressor gene, named for its ability to hinder cancer cell growth, Miano honed in on AKAP12 to see if it might be a target of retinoids in the context of vascular disease.
They found that a specific section of the complex AKAP12 gene, called AKAP12 beta, is extremely responsive to treatment with the drug, and that ramping up its activity reduces vascular cell growth.