angioimmunoblastic T-cell lymphoma

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angioimmunoblastic T-cell lymphoma

rare subtype of lymphoma characterized by generalized lymphadenopathy, prominent systemic symptoms, fever, weight loss, skin rash, polyclonal gammopathy, circulating immune complexes and autoantibodies, and a tendency to infection complication. Previously referred to as angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). Diagnosis is often difficult because of the varying clinicopathologic picture. Fewer than one third of the patients can be expected to have long-term remissions even after multiagent chemotherapy. Complete remissions have been reported after the use of interferon-α and cyclosporine.

angioimmunoblastic T-cell lymphoma

A lymphoma affecting the elderly characterised by generalised lymphadenopathy and systemic symptoms.
 
DiffDx
Drug reaction (e.g., antibiotics, phenytoin), T-cell-rich diffuse large B cell lymphoma, classical Hodgkin lymphoma, angioimmunoblastic lymphadenopathy with dysproteinaemia, peripheral T-cell lymphoma (undifferentiated).