AIM2

AIM2

A gene on chromosome 1q22 that encodes an IFN-gamma-induced tumour suppressor of the IFI20X/IFI16 family, which is thought to play a role in tumour regression and may control cell proliferation.
References in periodicals archive ?
Jude Children's Research Hospital have discovered how an immune system protein, called AIM2 (Absent in Melanoma 2), plays a role in determining the aggressiveness of colon cancer.
Since reduced AIM2 activity in colorectal cancer patients is associated with poor survival, it might be useful to detect the level of AIM2 expression in polyps taken from colonoscopy and use this as one of the biomarkers for prognosis," Kanneganti said.
AIM2 protein levels in response to a Human Papillomavirus and the impact of infectious microbes in cervical cancer cell lines.
8] AIM2, second interviewee from a Moroccan Immigrant association.
They have discovered a protein called AIM2 that detect and reacts to dangerous cytoplasmic DNA produced by viral or microbial pathogens.
When AIM2 binds to the foreign DNA, it triggers cytoplasmic protein called ASC, which along with the AIM2 activates the production of interleukin1beta and other inflammatory cytokines that cause inflammation.
In a mouse model of IL-23-induced psoriasis, the inflammasome components NLRP3 and AIM2 were up-regulated and IL-1 was increased compared to control animals.
Inflammasome is a multi-protein complex, and its components include NLRP3 and AIM2 for recognition of cellular nucleic acids.
The new findings also revealed how immune cells switch on genes that activate microbe-killing machinery called the AIM2 inflammasome.
The inflammasome that attacks the tularemia bacterium is triggered by the sensor protein AIM2 that recognizes the tularemia DNA.
The six tumor-associated antigens used in ICT-107 are AIM2, Her-2/neu, gp-100, MAGE-1, TRP-2 and IL13Ra2.
These CSCs were found to have significantly higher expressions of three antigens targeted by ICT-107--Her-2/neu, AIM2, and TRP-2--than the cells that make up the bulk of the tumor.