AIF1


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AIF1

A gene on chromosome 6p21.3 that encodes allograft inflammatory factor 1, an actin-binding, cytokine- and interferon-induced protein that regulates proliferation of vascular smooth muscle cells, resulting in an anti-inflammatory response to vessel wall trauma.

AIF1 activities
• Enhances lymphocyte migration and actin-bundling activity of LCP1.
• Plays a role in RAC signalling, phagocytosis and in vascular inflammation.
• Promotes proliferation of vascular smooth muscle cells and of T cells.
• May play a role in macrophage activation and function.
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References in periodicals archive ?
Genotypes of the AIF1 polymorphisms were in Hardy-Weinberg equilibrium (p>0.
In this study, we examined whether AIF1 gene rs2269475: C>T polymorphism is associated with RA development and disease activity.
The results of present study suggest that AIF1 gene rs2269475 polymorphism is associated with RA development; however, has no influence on disease activity.