AIDS cholangiopathy

(redirected from AIDS-associated sclerosing cholangitis)

AIDS cholangiopathy

biliary duct disease that is a complication of acquired immunodeficiency syndrome. The most common effect is primary sclerosing cholangitis; some patients also have dysfunction of the sphincter of Oddi. This syndrome is most commonly caused by Cryptosporidium parvum, but it can also be caused by Microsporidium, cytomegalovirus, and Cyclospora cayetanensis. Its occurrence has been reduced by the advent of highly active antiretroviral therapy.

AIDS cholangiopathy

A bile obstruction syndrome caused by infection-related strictures of the biliary tract, which occurred in up to 25% of patients in the pre-HAART (highly active antiretroviral therapy) era; it is more common in those with CD4 counts of < 100/mm3.

Clinical findings
Chronic right upper quadrant and epigastric pain, low-grade fever, diarrhoea, cholestasis with bile duct ectasia, bile duct defects, papillary stenosis.
 
Aetiology
Cryptosporidium parvum, CMV, Microsporidium, Enterocytozoon bieneusi, Encephalitozoon intestinalis, Mycobacteriium tuberculosis.
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