ATIC

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ATIC

A gene on chromosome 2q35 that encodes a bifunctional protein that catalyses the last two steps in purine biosynthesis.

Molecular pathology
ATIC mutation causes AICA-ribosiduria.
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AICAR normally works by activating the body's metabolic "master switch," an enzyme called AMPK that, among other things, influences muscle activity.
The team found that AICAR reduces calcium leakage from RYR1, thus diminishing heat-induced contractions, muscle damage, and death.
Abbreviations: PPAR[alpha], peroxisome proliferator-activated receptor alpha; PGC-1[alpha], peroxisome proliferator-activated receptor gamma coactivator-1 alpha; CPT1, carnitine palmitoyltransferase 1; AMPK, AMP-activated protein kinase; AICAR, 5-aminoimidazole-4-carboxamide-1-[beta]-D-riboside; cpdC, compound C; HSL, hormonesensitive lipase; ATGL, adipose triglyceride lipase; ACC, acetyl-CoA carboxylase; FAO, fatty acid oxidation; CRE, cAMP response element; CREB, CRE-binding protein; SIRT1, silent information regulator T1; HDAC, histone deacetylase; ERK1/2, extracellular signal-regulated protein kinases 1 and 2; EMSA.
Drugs such as Metformin and AICAR work by stimulating an enzyme called AMP kinase (AMPK) which regulates energy within our cells - the very enzyme that hepatitis C virus represses to enable it to replicate.
Subsequent in vivo studies confirmed that by increasing intracellular AICAR accumulation, methotrexate increased adenosine concentration and diminished leukocyte accumulation in inflammatory exudates in the murine air pouch model.
For example, Dervieux and coworkers suggested that combinations of functionally significant SNPs in RFC1, AICAR transformylase, and TS are more predictive of methotrexate response than any single SNP.
Professor Greg Florant, a biologist at the Colorado State University, discovered he could slowly release a molecule called AICAR into yellow-bellied marmots that activates a neurological pathway driving food intake and stimulates appetite.
New research suggests that anti-diabetic drugs such as metformin and AICAR, currently used to fight obesity, may benefit patients with hepatitis C by preventing replication of the virus in the body.
AMPK pathway is a major regulator of GLUT4 translocation in response to some antidiabetic agents such as AICAR and metformin (Ju et al.
AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model.