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antihemophilic factor (factor VIII, one of the coagulation factors).

antihemophilic factor (AHF, factor VIII)

Advate, Alphanate, Hemofil M, Koate-DVI, Kogenate FS, Monarc-M, Monoclate-P, Recombinate, ReFacto

Pharmacologic class: Hemostatic

Therapeutic class: Antihemophilic

Pregnancy risk category C

FDA Box Warning

• Drug is made from human plasma and may contain infectious agents. Plasma donor screening, testing, and inactivation or removal methods reduce this risk.


Promotes conversion of prothrombin to thrombin (necessary for hemostasis and blood clotting). Also replaces missing or deficient clotting factors, thereby controlling or preventing bleeding.


I.V. injection: 250, 500, 1,000, or 1,500 international units/vial in numerous preparations

Indications and dosages

Spontaneous hemorrhage in patients with hemophilia A (factor VIII deficiency)

Adults and children: Dosage is highly individualized, calculated as follows: AHF required (international units) equals weight (kg) multiplied by desired factor VIII increase (% of normal) multiplied by 0.5.

To control bleeding, desired factor VIII level is 20% to 40% of normal for minor hemorrhage; 30% to 60% of normal for moderate hemorrhage; or 60% to 100% of normal for severe hemorrhage. To prevent spontaneous hemorrhage, desired factor VIII level is 5% of normal.


• Hypersensitivity to drug or to mouse, hamster, or bovine protein


Use cautiously in:
• hepatic disease
• blood types A, B, and AB
• patients receiving factor VIII inhibitors
• pregnant patients
• neonates and infants.


• Before giving, verify that patient has no history of hypersensitivity to drug or to mouse, hamster, or bovine protein.
• Follow prescriber's instructions regarding hepatitis B prophylaxis before starting therapy.
• Refrigerate concentrate until ready to reconstitute drug; then warm to room temperature before mixing.
• Roll bottle gently between hands until drug is well-mixed.
• Give a single dose over 5 to 10 minutes at rate of 2 to 10 ml/minute, as appropriate.
• After drug is reconstituted, don't refrigerate, shake, or store near heat.
• Don't mix with other I.V. solutions.
• Use plastic (not glass) syringe and filter.

Adverse reactions

CNS: headache; lethargy; fatigue; dizziness; jitteriness; drowsiness; depersonalization; tingling in arms, ears, and face

CV: chest tightness, angina pectoris, tachycardia, slight hypotension, thrombosis

EENT: blurred or abnormal vision, eye disorder, otitis media, epistaxis, rhinitis, sore throat

GI: nausea, vomiting, diarrhea, constipation, stomachache, abdominal pain, gastroenteritis, anorexia,

Hematologic: forehead bruises, increased bleeding tendency, thrombocytopenia, hemolytic anemia, intravascular hemolysis, hyperfibrinogenemia

Hepatic: hepatitis B transmission Musculoskeletal: myalgia, muscle weakness, bone pain, finger pain

Respiratory: dyspnea, coughing, wheezing, bronchospasm

Skin: rash, acne, flushing, diaphoresis, urticaria

Other: taste changes, allergic reaction, fever, chills, cold feet, cold sensations, infected hematoma, stinging at injection site, anaphylaxis, human immunodeficiency virus transmission


Drug-diagnostic tests.Bilirubin, creatine kinase: increased levels

Hemoglobin, platelets: decreased values

Patient monitoring

Monitor for signs and symptoms of anaphylaxis and hemolysis.

Watch for bleeding tendency and hemorrhaging.
• Check vital signs regularly.
• Monitor CBC and coagulation studies.

Assess for severe headache (may indicate intracranial hemorrhage).

Patient teaching

Tell patient to immediately report signs and symptoms of allergic response or bleeding tendency.
• Caution patient not to use aspirin during therapy.
• Instruct patient to contact prescriber if drug becomes less effective.
• Tell patient to report signs or symptoms of hepatitis B.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and vision.
• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.
• Notify patient that he'll undergo regular blood testing during therapy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.


Abbreviation for antihemophilic factor A.


antihemophilic factor (coagulation factor VIII).


antihemophilic factor


abbreviation for antihemophilic factor.


Abbreviation for:
accelerated hyperfractionation
acute heart failure
acute hepatic failure
American Health Foundation
American Hospital Formulary
anterior heart field
antihemophilic factor (see there)
Argentine haemorrhagic fever


Abbreviation for antihemophilic factor A.


n the abbreviation for antihemophilic factor. See also factor VIII.


antihemophilic factor (clotting factor VIII).
References in periodicals archive ?
According to AHF, the mismanagement at FDA reaches beyond HIV.
We are honored to have AHF/Positive Healthcare Florida nurses and case managers participating in outreach efforts here in Florida as we continue to expand our role as community partners in the local fight against HIV/AIDS," said Gene Bundrock, Statewide Director, AHF Positive Healthcare Florida.
AHF Ukraine aimed to get 2,000 people tested and to distribute 30,000 condoms through these events.
Following is a letter that AHF Sacramento lobbyist Rand Martin sent to the Governor detailing AIDS Healthcare Foundation's concerns regarding these potentially devastating cuts with a plea that the Governor intervene and reverse this Medi-Cal cut.
In September 2012, AHF President Michael Weinstein met with three representatives of the Auditor Controller as well as a representative from one of the Board of Supervisors' offices.
The crowd response on site by attendees of both Jingle Ball and at LA Live was really good," said AHF Public Health Division Program Manager Rod NuSez.
AHF is also calling on Mayor Antonio Villarraigosa to meet with Housing Department officials to help us reach a mutually agreeable solution so that AHF can continue to deliver appropriate and needed HIV/AIDS services to people in Los Angeles at Linn House.
Himanta Biswa Sarma, the Honorable Medical Minister of Assam, who unveiled the clinic dedication plaque with AHF President Michael Weinstein, remarked, "We are grateful to AHF for its concern and deep commitment for people living with HIV/AIDS in Assam, and we encourage AHF to assist in developing a truly excellent Center for Assam which will cater not only to the health needs of Assam, but also to many of the neighboring North Eastern States of India.
This new partnership between NACO and AHF- India Cares should help break the chain of new infections in India by helping organizations such as AHF and India Cares usher more HIV positive individuals and those already living with AIDS into care and treatment.
As a leader in the bleeding disorders community, AHF takes that dedication even further with the launch of their new website.
AIDS Healthcare Foundation (AHF) filed a lawsuit in California against pharmaceutical giant Johnson & Johnson and its subsidiaries (J&J) alleging that the companies have failed to fully satisfy their obligations with respect to the drugs they sold to AHF over a period of many years, under the 340B Program, a Federal drug discount program designed to stretch scarce Federal resources as far as possible for safety net healthcare providers such as AHF.
AHF patients require urgent treatment so prompt decision-making to stop heart failure worsening is crucial in spite of patients often having diverse clinical profiles.