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antihemophilic factor (factor VIII, one of the coagulation factors).

antihemophilic factor (AHF, factor VIII)

Advate, Alphanate, Hemofil M, Koate-DVI, Kogenate FS, Monarc-M, Monoclate-P, Recombinate, ReFacto

Pharmacologic class: Hemostatic

Therapeutic class: Antihemophilic

Pregnancy risk category C

FDA Box Warning

• Drug is made from human plasma and may contain infectious agents. Plasma donor screening, testing, and inactivation or removal methods reduce this risk.


Promotes conversion of prothrombin to thrombin (necessary for hemostasis and blood clotting). Also replaces missing or deficient clotting factors, thereby controlling or preventing bleeding.


I.V. injection: 250, 500, 1,000, or 1,500 international units/vial in numerous preparations

Indications and dosages

Spontaneous hemorrhage in patients with hemophilia A (factor VIII deficiency)

Adults and children: Dosage is highly individualized, calculated as follows: AHF required (international units) equals weight (kg) multiplied by desired factor VIII increase (% of normal) multiplied by 0.5.

To control bleeding, desired factor VIII level is 20% to 40% of normal for minor hemorrhage; 30% to 60% of normal for moderate hemorrhage; or 60% to 100% of normal for severe hemorrhage. To prevent spontaneous hemorrhage, desired factor VIII level is 5% of normal.


• Hypersensitivity to drug or to mouse, hamster, or bovine protein


Use cautiously in:

• hepatic disease

• blood types A, B, and AB

• patients receiving factor VIII inhibitors

• pregnant patients

• neonates and infants.


• Before giving, verify that patient has no history of hypersensitivity to drug or to mouse, hamster, or bovine protein.

• Follow prescriber's instructions regarding hepatitis B prophylaxis before starting therapy.

• Refrigerate concentrate until ready to reconstitute drug; then warm to room temperature before mixing.

• Roll bottle gently between hands until drug is well-mixed.

• Give a single dose over 5 to 10 minutes at rate of 2 to 10 ml/minute, as appropriate.

• After drug is reconstituted, don't refrigerate, shake, or store near heat.

• Don't mix with other I.V. solutions.

• Use plastic (not glass) syringe and filter.

Adverse reactions

CNS: headache; lethargy; fatigue; dizziness; jitteriness; drowsiness; depersonalization; tingling in arms, ears, and face

CV: chest tightness, angina pectoris, tachycardia, slight hypotension, thrombosis

EENT: blurred or abnormal vision, eye disorder, otitis media, epistaxis, rhinitis, sore throat

GI: nausea, vomiting, diarrhea, constipation, stomachache, abdominal pain, gastroenteritis, anorexia,

Hematologic: forehead bruises, increased bleeding tendency, thrombocytopenia, hemolytic anemia, intravascular hemolysis, hyperfibrinogenemia

Hepatic: hepatitis B transmission Musculoskeletal: myalgia, muscle weakness, bone pain, finger pain

Respiratory: dyspnea, coughing, wheezing, bronchospasm

Skin: rash, acne, flushing, diaphoresis, urticaria

Other: taste changes, allergic reaction, fever, chills, cold feet, cold sensations, infected hematoma, stinging at injection site, anaphylaxis, human immunodeficiency virus transmission


Drug-diagnostic tests. Bilirubin, creatine kinase: increased levels

Hemoglobin, platelets: decreased values

Patient monitoring

Monitor for signs and symptoms of anaphylaxis and hemolysis.

Watch for bleeding tendency and hemorrhaging.

• Check vital signs regularly.

• Monitor CBC and coagulation studies.

Assess for severe headache (may indicate intracranial hemorrhage).

Patient teaching

Tell patient to immediately report signs and symptoms of allergic response or bleeding tendency.

• Caution patient not to use aspirin during therapy.

• Instruct patient to contact prescriber if drug becomes less effective.

• Tell patient to report signs or symptoms of hepatitis B.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and vision.

• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.

• Notify patient that he'll undergo regular blood testing during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.


Abbreviation for antihemophilic factor A.


antihemophilic factor (coagulation factor VIII).


antihemophilic factor


abbreviation for antihemophilic factor.


Abbreviation for:
accelerated hyperfractionation
acute heart failure
acute hepatic failure
American Health Foundation
American Hospital Formulary
anterior heart field
antihemophilic factor (see there)
Argentine haemorrhagic fever


Abbreviation for antihemophilic factor A.


n the abbreviation for antihemophilic factor. See also factor VIII.


antihemophilic factor (clotting factor VIII).
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The study consecutively enrolled patients in whom AHF was diagnosed in the ED at participating hospitals between January 1, 2011, and September 23, 2012.
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But unlike when the society was receiving annual funding from AHF, there is no guarantee that next year's funding will allow for the same inclusion.
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The primary endpoints of the study, which was investigating the efficacy, safety and tolerability of RLX030 (serelaxin) in patients with acute heart failure (AHF), were reduction in cardiovascular death through day 180 and reduced worsening heart failure through day five when added to standard therapy in patients with AHF.
Covering AHF land, the new specialty milk processing and bottling facility will be 100% backed by the Chinese customer, Australian Lian He Pty Ltd.
AHF CEO 'Dato' Tayyib Ikram, who is here on an invitation from the Oman Hockey Association (OHA) to attend the final of His Majesty's Cup Hockey Championship, revealed the Asian body's attempt take three of the GCC nations into the fold and plans for the development of hockey in the region.
com)-- AHF FC has been awarded FA Charter Status for another year.