AGPAT2

AGPAT2

A gene on chromosome 9q34.3 that encodes 1-acylglycerol-3-phosphate O-acyltransferase 2, a member of the 1-acylglycerol-3-phosphate O-acyltransferase family, which is located in the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in phospholipid biosynthesis.

Molecular pathology
AGPAT2 mutations cause congenital generalised lipodystrophy (Berardinelli Seip syndrome) type 1.
References in periodicals archive ?
The causal gene, AGPAT2, which is involved in the synthesis of phosphatidic acid and triglycerides, was removed in the mice, resulting in rodents with generalized lipodystrophy.
3 Insulin resistance Generalized lipodystrophy AGPAT2 9q34.
We found a trend for more AGPAT1 transcripts in mammary tissues and a fivefold expression of AGPAT2 in liver.
In 2002, the mutated gene, AGPAT2, linked to congenital generalized lipodystrophy, was identified.