EIF2C1

(redirected from AGO1)

EIF2C1

A gene on chromosome 1p34.3 that encodes a protein required for RNA-mediated gene silencing, binding to short RNAs, such as microRNAs or short interfering RNAs, and repressing the translation of mRNAs complementary to them. EIF2C1 lacks endonuclease activity and does not appear to cleave target mRNAs. It is required for transcriptional gene silencing of promoter regions which are complementary to bound short anti-gene RNA.
References in periodicals archive ?
Moreover, seven SNPs in the 5 genes (DNMT3L, AGO1, AGO2, HDAC5, and PRKAG3) were non-significantly associated with all of the beef carcass and quality traits in the Snow Dragon beef population.
However, several lines of recent evidence, including from the host laboratory, suggest the existence of as yet unidentified functions for AGO1 in the nucleus; conclusive evidence for nuclear PTGS was, moreover, recently obtained in soybean.
1) analyse the nature of sRNA bound to nuclear AGO1 and identify their origin and targets;
The study, entitled, "Distinct Catalytic and Non-Catalytic Roles of ARGONAUTE4 in RNA-directed DNA Methylation," describes how 454 Sequencing(TM) was used to elucidate the small RNAs associated with AGO4 and the AGO1 protein.
Arnell also offers corporate identity, design, traditional and interactive advertising services as well as consulting through such additional specialist companies as Arnell CI, Arnell 360, AGO1 and Arnell Group Brand Consulting.