acute generalized exanthematous pustulosis

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acute generalized exanthematous pustulosis

Abbreviation: AGEP.
A rare but severe allergic reaction to a drug, characterized by a widespread pustular rash, fever, and a high white blood cell count. It usually resolves within a few weeks after one stops taking the drug that caused the reaction.
See also: pustulosis
References in periodicals archive ?
Although the median age of occurrence is 56 years, people of all ages can develop AGEP.
Fever, leukocytosis with an elevated neutrophil count (greater than 7,000 /microL), and mild eosinophilia are commonly observed during the acute phase of AGEP.
Discontinuation of the offending agent and symptomatic treatment are generally agreed in the treatment of AGEP.
Macmillan, in 1973, was probably the first author to describe a case of AGEP.
7,8] Thorough medical history, drug history, with clinicopathologic correlation is important in a patient presenting with acute diffuse pustular lesions to make a diagnosis of AGEP.
The history, clinical manifestation, and laboratory investigation were suggestive of AGEP.
A lymphocyte transformation test was positive for AGEP.
However, it was later recognised as a distinct drug eruption and in effect, some cases previously reported as 'drug-induced pustular psoriasis' were actually AGEP.
Other medications, such as anti fungal drugs, non steroid anti-inflammatory drugs, analgesics, antiarrhythmic, anticonvulsant and antidepressant drugs are also reported to induce AGEP.