AFF4


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AFF4

A gene on chromosome 5q31 that encodes a protein which may play a role in transcriptional regulation.
References in periodicals archive ?
The central research finding is that mutations in the gene AFF4 disrupt a crucial group of proteins called the super elongation complex (SEC).
The mutated AFF4 gene produces mutated proteins, which then accumulate and cause a cascade of abnormalities in other genes controlled by AFF4.
Germline Gain-of-Function Mutations in AFF4 Cause a Novel Syndrome and Functionally Link the Super Elongation Complex and Cohesin," Nature Genetics, published online March 2, 2015.