anadamide

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anadamide

(an-ad'a-mīd),
Endogenous ligand for the cannabinoid receptor.

anadamide

An endogenous cannabinoid neurotransmitter, which is synthesised from N-arachidonoyl phosphatidylethanolamine and degraded by fatty acid amide hydrolase. Anadamide has CNS effects when it binds to CB1 cannabinoid receptor, and peripheral effects when it binds to CB2. It acts as an endogenous ligand for vanilloid receptors, which transduce acute and inflammatory pain signals, by activating protein kinase C. It also impairs working memory, is important for implantation of early embryos at the blastocyst stage and appears to be involved in regulating feeding behaviour and neural generation of motivation and pain.
References in periodicals archive ?
401(k) plan assets should be used to ensure that a bypass trust will fully use the AEA.
On Y's death, her share of the remaining undistributed IRA will pass to a bypass trust to fully use the $650,000 AEA.
AEA objected in particular to the proportion of students taking remedial training classes, which took time and money away from teaching college-level courses.
I think that the numbers are stunning," said Executive Director Pierce Allman, who conducted a multimedia extravaganza featuring four presentations with two large screen displays to nearly 3,000 AEA members.
Troux's AEA Platform incorporates the Cognos ReportNet[TM] reporting system to create snapshots of subsets of Metis Server data, which gives every person in an organization the visibility and comprehension of data needed to make fact-based decisions.