adverse drug reactions

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adverse drug reactions

; ADRs un-intended and harmful effect of drug therapy, neither intended nor expected in normal therapeutic use (Table 1)
Table 1: Types of adverse drug reaction
TypeFeatures
ACommon, dose-related, predictable, augmented drug effect in patients showing excessive response to normal drug dosage; managed by dose reduction
BBizarre, rare, unpredictable, non-dose-related, immunological-based, severe drug reaction; drug must be withdrawn immediately
CGradual reduction of drug effectiveness over time; due to adaptation/habituation
DDelayed effects of drug
EEnd-of-use withdrawal reaction
FUnexpected failure of therapeutic effect, possibly due to interaction with another drug