ADRB2


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ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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There is some evidence which suggests that ADRB2 gene is related to the endurance and recovery of exercise in humans (Zieker et al.
Polymorphisms of IL4, IL13, and ADRB2 genes in COPD.
005), whereas haplotype associations in the ADRB2 and GSTP1 genes were not significant after correction for multiple tests (data not shown).
We observed no significant interactions between variants in the TNF and ADRB2 genes and exposure to traffic [NO.
Methods to routinely detect the common codon 16 and 27 polymorphisms have relied on preliminary amplification of ADRB2 sequences by PCR and subsequent identification by a variety of methods (15).