ADRA2A

ADRA2A

A gene on chromosome 10q24-q26 that encodes alpha-2A-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS, smooth muscle contraction and thermoregulation.
 
ADRA2A agonists
Oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
 
ADRA2A antagonists
Yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
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References in periodicals archive ?
Called yohimbine, the drug is effective in people with a variant of a gene called ADRA2A, researchers report October 8 in Science Translational Medicine.
Approximately 40 percent of people with type 2 diabetes have a version of the ADRA2A gene that makes insulin-releasing cells in the pancreas more sensitive to the stress hormone adrenaline.
Rosengren and colleagues recruited 49 people with type 2 diabetes, including 28 who have the insulin-reducing version of ADRA2A.
Thus, polymorphisms in the ADRA2A gene, which encodes adrenergic receptors that inhibit norepinephrine release from the neuron, are associated with certain aspects of the stress response as determined by measuring blood pressure and heart rate (Finley et al.
They looked initially at four genes frequently implicated in ADHD - DRD4, DAT, COMT and ADRA2A.
The ADRA2A locus is associated with impaired insulin granule docking and reduced [beta]-cell exocytosis in congenic GK (Goto-Kakizaki) rats (65).