ADRA2A

(redirected from ADRA2)

ADRA2A

A gene on chromosome 10q24-q26 that encodes alpha-2A-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS, smooth muscle contraction and thermoregulation.
 
ADRA2A agonists
Oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
 
ADRA2A antagonists
Yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
Mentioned in ?
References in periodicals archive ?
reported that human carriers of the ADRA2A risk variant (rs553668) have reduced fasting insulin and decreased insulin secretion (65) as a consequence of increased expression of the ADRA2 receptor in pancreatic islets.