ADPKD


Also found in: Acronyms.

ADPKD

 
autosomal dominant polycystic kidney disease.

ADPKD

abbreviation for autosomal-dominant polycystic kidney disease.

autosomal dominant polycystic kidney disease

A common (1:400–1:1000) autosomal dominant condition (OMIM:173910), which causes 6–9% of end-stage renal disease in developed countries. ADPKD first appears in adults with upper quadrant tenderness; extrarenal disease is due to defective extracellular matrix, with hepatic cysts, diverticulosis, berry and abdominal aneurysms, annuloaortic ectasia and valvular regurgitation.

Clinical findings
Acute or subacute onset of azotaemia and hypertension, due to increased activity of the renin-angiotensin-aldosterone (RAA) system, possibly related to the ischaemic pressure induced by the expanding cysts.

Lab
Anaemia, increased ESR, increased WBCs.
 
Diagnosis
Ultrasonography.

ADPKD

Autosomal dominant polycystic kidney disease, see there.
References in periodicals archive ?
Her two children were also evaluated for ADPKD, and they both did not have any evidence of disease at present, and hence they are kept under followup.
All children from the age of ~10 years and all adults from ADPKD families should be screened using magnetic resonance imaging (MRI) or computed tomography (CT), but not renal ultrasound (due to the considerable number of negative results).
Approximately half of people with ADPKD will require a kidney transplant or dialysis by the age of 54.
To our knowledge, this is the first description of a pure laparoscopic approach to unilateral nephrectomy for ADPKD in a horseshoe kidney.
When the researchers examined these cells under the microscope, they discovered that the polycystin-2 protein traveled normally to the antenna, or cilium, in cells from ARPKD patients, but it had trouble reaching the antenna in ADPKD patients.
La ADPKD puede ser causada por mutaciones en dos genes diferentes; la mas frecuente es la ADPKD 1 (85% de los casos) causada por mutaciones en el gen PKD1 o tambien llamado policistina 1.
Early research reveals that certain signals within cells may contribute to cyst growth in ADPKD patients.
ADPKD is a fairly common heritable condition, with a prevalence rate of 1 in 400 to 1 in 1000 persons.
Patients with ADPKD generally present with enlarged kidneys and the formation of cysts, not only in the kidneys but also in organs such as the liver, pancreas, and spleen.
The results are intended to form the basis of regulatory filings in multiple countries seeking a new drug approval in ADPKD
ADPKD is usually asymptomatic until the age of 30-40 years and is rarely seen in foetal life.