ARF6

(redirected from ADP-ribosylation factor 6)
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ARF6

A gene on chromosome 14q21.3 that encodes a protein of the ADP-ribosylation factor gene family, which encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and are involved in vesicular trafficking as phospholipase D activators. ARF6 localises to the plasma membrane and regulates vesicular trafficking, membrane lipid remodelling and actin remodelling.
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ADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways.
Endocytosis of CT may follow one of three pathways: (i) lipid raft/caveolae mediated endocytic pathway, (ii) clathrin mediated endocytic pathway, or (iii) ADP-ribosylation factor 6 (Arf6)-associated endocytic pathway.

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