ADP ribosylation


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ADP ri·bo·syl·a·tion

covalent attachment of an ADP-ribosyl moiety to a macromolecule, for example, the action of diphtheria toxin.
References in periodicals archive ?
The entry of CTA1 to the cell cytosol is the key step for intoxication because CTA1 catalyzes the ADP ribosylation of the trimeric Gsa component of AC.
These results were reported at the 11th International Symposium on ADP Ribosylation, DNA Repair and Signal Transduction, which was held recently in Strasbourg, France.
The SS1P molecule is an ingenious example of protein engineering: the native Pseudomonas exotoxin protein consists of three domains: domain I targets cell surface receptors, domain II functions to translocate the molecule across a cell membrane and into the cell interior, and domain III catalyzes irreversible ADP ribosylation and inactivation of elongation factor 2 (EF2).
The ADP ribosylation activity of CT resides in CTA1.
These results were reported at the 11th International Symposium on ADP Ribosylation, DNA Repair, and Signal Transduction, which was held recently in Strasbourg, France.