In vitro ADMET
testing -- In vivo ADMET
applications -- In silico ADMET
As a programme progresses into the later stages of hit-to-lead, alongside the in vitro and in vivo assays that will be used to directly assess ADMET
properties, the computational chemistry team constructs the models that are more specific to the chemical series being investigated.
New option to choose which ADMET
properties to calculate and display
In-silico computational biology: In-silico ADMET
(Absorbtion, Distribution, Metabolism, Excretion, Toxicology) prediction based on genetic algorithm neural network software
Robert Fraczkiewicz, team leader for ADMET
cheminformatics at Simulations Plus, said: "ADMET
Predictor has been evolving for more than 11 years, beginning as two products - QMPRPlus[TM] for property predictions and QMPRchitect[TM] for building predictive models - that were then combined, with QMPRchitect becoming the ADMET
Modeler[TM] module in ADMET
The allowance of the European B-CLEAR(R) patent application strengthens Qualyst's position as a global ADMET
technology provider, and represents the latest progress in our rapidly expanding intellectual asset portfolio," said Marc Sedam, Qualyst's vice president for corporate development.
Company Now Owns IP in ADMET
Predictor[TM] Enslein Metabolism Module
This report explores novel preclinical models that show promise to expedite and improve the target validation and lead optimization timeline and discusses the various advantages and disadvantages of ADMET
screening technologies to provide insight on which models or systems may enhance the R&D function of pharmaceutical and biotechnology organisations.
Building new predictive models for affinity against the parasite using the ADMET
Modeler[TM] module within ADMET
The program's tight integration with our best-in-class ADMET
Predictor[TM] software provides what we believe is the most powerful in silico molecule design capability available today.
With new drug development costs estimated at over $1 billion, it's imperative that biotech and pharma firms use ADMET
tools intelligently and as early as possible in the drug discovery and development process to get a better handle on costs," notes John Sterling, Editor-in-Chief, GEN.
Last week, we announced the release of our new MedChem Designer[TM] molecule drawing software that integrates with our ADMET
Predictor[TM] and MedChem Studio[TM] programs.