ADMET


Also found in: Acronyms.

ADMET

An acronym for absorption, distribution, metabolism, excretion, and toxicity. These are key elements that determine the safety, uptake, elimination, metabolic behavior, and effectiveness of drugs.
References in periodicals archive ?
In vitro ADMET testing -- In vivo ADMET applications -- In silico ADMET uses.
As a programme progresses into the later stages of hit-to-lead, alongside the in vitro and in vivo assays that will be used to directly assess ADMET properties, the computational chemistry team constructs the models that are more specific to the chemical series being investigated.
New option to choose which ADMET properties to calculate and display
In-silico computational biology: In-silico ADMET (Absorbtion, Distribution, Metabolism, Excretion, Toxicology) prediction based on genetic algorithm neural network software
Robert Fraczkiewicz, team leader for ADMET cheminformatics at Simulations Plus, said: "ADMET Predictor has been evolving for more than 11 years, beginning as two products - QMPRPlus[TM] for property predictions and QMPRchitect[TM] for building predictive models - that were then combined, with QMPRchitect becoming the ADMET Modeler[TM] module in ADMET Predictor.
The allowance of the European B-CLEAR(R) patent application strengthens Qualyst's position as a global ADMET technology provider, and represents the latest progress in our rapidly expanding intellectual asset portfolio," said Marc Sedam, Qualyst's vice president for corporate development.
Company Now Owns IP in ADMET Predictor[TM] Enslein Metabolism Module
This report explores novel preclinical models that show promise to expedite and improve the target validation and lead optimization timeline and discusses the various advantages and disadvantages of ADMET screening technologies to provide insight on which models or systems may enhance the R&D function of pharmaceutical and biotechnology organisations.
Building new predictive models for affinity against the parasite using the ADMET Modeler[TM] module within ADMET Predictor[TM].
The program's tight integration with our best-in-class ADMET Predictor[TM] software provides what we believe is the most powerful in silico molecule design capability available today.
With new drug development costs estimated at over $1 billion, it's imperative that biotech and pharma firms use ADMET tools intelligently and as early as possible in the drug discovery and development process to get a better handle on costs," notes John Sterling, Editor-in-Chief, GEN.
Last week, we announced the release of our new MedChem Designer[TM] molecule drawing software that integrates with our ADMET Predictor[TM] and MedChem Studio[TM] programs.