is the abbreviation for absorption distribution, metabolism and elimination, a pharmacology and pharmacokinetics term that describes the disposition of a drug or compound inside the human body.
For continuing ADME
studies in animals, Sprague-Dawley rats containing identical homozygous efflux transporter gene knockouts arc also available for purchase from Sigma Advanced Genetic Engineering (SAGE) Labs.
Certain expert contract research organizations (CROs) have a wealth of ADME
experience and expertise, and can adapt and tailor their services to meet the client's needs and, as these can be called upon as required, can be an effective way to control costs.
2 Optimal ADME
Properties for Clinical Candidate and Investigational New Drug (IND) Package
Harder TC, Kenter M, Appel MJ, Roelke-Parker ME, Barrett T, Osterhaus ADME
Celerion, the premier provider of innovative early stage drug development solutions, is pleased to announce that it has expanded its ADME
(Absorption, Distribution, Metabolism and Excretion) Suite in Lincoln, Nebraska USA.
She directed the Drug Disposition component, including ADME
and PK/PD, in support of discovery and development of small and large NMEs.
, Groen J, Spijkers HEM, Broeders HWJ, UytdeHaag FGCM, de Vries P, et al.
In recent years, the biotechnology and pharmaceutical industries have been genotyping ADME
genes earlier in the drug development pipeline to help reduce the significant costs associated with failed drug trials and hospitalizations due to adverse events.
M2 PHARMA-October 4, 2011-Cyprotex launches genomic ADME
service(C)2011 M2 COMMUNICATIONS
THE DRUG DISCOVERY COMMUNITY recognizes that evaluation and optimization of ADME
(absorption, distribution, metabolism and excretion) profiles early in the drug discovery process can significantly contribute to reducing the attrition rate of compounds later in development due to poor pharmacokinetic (PK) properties (1), (2).
This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME
for medicinal chemists.