ADIPOQ


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Related to ADIPOQ: Adiponectin, Resistin

ADIPOQ

The gene on chromosome 3q27 which encodes adiponectin, a key adipokine involved in the control of fat metabolism and insulin sensitivity. ADIPOQ is only expressed only in adipose tissue.
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Data on nonsynonymous variations of the ADIPOQ gene were collected from the database of SNPs (db SNP) located on the homepage of the National Center for Biotechnology Information website (http://www.
In case of ADIPOQ, 3D crystallographic structure was not available in PDB.
By examining ADIPOQ gene using the dbSNP and HGVD databases, a total of 58 nonsynonymous SNPs were found.
Among the above, 16 (29%) common ADIPOQ gene variants, namely, c.
ADIPOQ was predominantly expressed in backfat, and was also detectable in muscle samples; however, at significantly (Pless than 0.
ADIPOQ expression has also been shown to differ between piglets with high (higher ADIPOQ level) and low birth weight (animals with lower ADIPOQ levels); however, such differences were not found at later (60, 80, and 110 kg) body weight stages (Cho et al.
The data presented here are the first published ADIPOQ, A-FABP, and LEP expression results for Mangalica and Duroc crossbred pigs.
Our data also indicate that ADIPOQ expression in muscle can be used as an indicator of IMF content.
ADIPOQ gene variations have also been associated with differential plasma adiponectin concentrations (11-18); in particular, the +45T>G and +276G>T gene variants and haplotypes carrying these specific variants were recently shown to be associated with decreased plasma adiponectin concentrations (30, 31), suggesting a functional involvement of the ADIPOQ gene in inflammatory responses via altered transcriptional activity.
Several studies have found associations of ADIPOQ variations with risk of cardiovascular disease in persons without (13) as well as with diabetes (14,19, 20), but none have evaluated associations with actual atherothrombotic events in a nondiabetic population.
Thus, the functionality of ADIPOQ gene variants and the pathophysiologic consequences of their altered transcriptional activity remain elusive.
In conclusion, these prospective data from a large cohort of apparently healthy Caucasian US men provide evidence of an association between specific ADIPOQ promoter variations/haplotypes tested and decreased risk of incident ischemic stroke.