ADH5


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ADH5

A gene on chromosome 4q23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. ADH5 has minimal activity for ethanol oxidation, but has a high activity for oxidation of long-chain aliphatic alcohols and oxidation of S-(hydroxymethyl) glutathione. The ADH5 protein product is critical in metabolic elimination of formaldehyde, a potent irritant and sensitising agent that causes lacrymation, rhinitis, pharyngitis and contact dermatitis.
References in periodicals archive ?
The product of the ubiquitously expressed ADH5 gene is the glutathione-dependent formaldehyde dehydrogenase (also known as nitrosoglutathione reductase [GSNOR]).
Moreover, noncoding SNPs in the region of ADH1A, ADH1B, and ADH1C have been associated with alcoholism and drinking phenotypes, as have SNPs in ADH7 and ADH5.
6 ADH4 ([pi][pi]) 30 ADH5 ([chi][chi]) >1,000 ADH7 ([sigma][sigma]) 30 [V.