ADH4


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ADH4

A gene on chromosome 4q21-24 that encodes a class-II alcohol dehydrogenase 4-pi subunit of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic
alcohols, hydroxysteroids and lipid peroxidation products. Class-II alcohol dehydrogenase exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols.
References in periodicals archive ?
6 ADH4 ([pi][pi]) 30 ADH5 ([chi][chi]) >1,000 ADH7 ([sigma][sigma]) 30 [V.
A single SNP located 136 basepairs (bp) upstream of the translational start site of ADH4 results in a two-fold difference in gene expression in vitro (Edenberg et al.
A study of 110 SNPs across all seven ADH genes demonstrated that variations in ADH4 most strongly affected risk for alcoholism in European-American families (Edenberg et al.
For example, ADH4 variants strongly affect alcoholism risk in populations of European descent (Edenberg et al.
ADH4 gene variation is associated with alcohol and drug dependence: Results from family controlled and population-structured association studies.
In addition, gastric ADH4 (Class IV ADH) activity was 177 percent higher in pregnant female rats compared with nonpregnant cohorts (Badger et al.
Giri and colleagues (1989) found ADH3 expressed in rat brain, and Martinez and colleagues (2001) found mRNA for ADH1 and ADH4 in rat brain cells.