ADH1B

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ADH1B

A gene on chromosome 4q21-23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism.
References in periodicals archive ?
Isoform Restriction (primer ID) Primer sequence enzyme ALDH2 (YC3) 5'-TTG GTG GCT AGA AGA TGT C-3' MboII ALDH2 (YC4) 5'-CCA CAC TCA CAG TTT TCT CTT-3' MboII ADH2 (A2F) 5'-ATT CTA AAT TGT TTA ATT CAA GAA G-3' MsII ADH2 (A2R) 5'-ACT AAC ACA GAA TTA CTG GAC-3' MsII ADH2 (424) 5'-TGG ACT CTC ACA ACA AGC ATG GT-3' AluI ADH2 (290) 5'-TTT CTT TGG AAA GCC CCC AT-3' AluI ADH2 (352) 5'-TCT TTC CTA TTG CAG TAG C-3' AluI ADH3 (321) 5'-GCT TTA AGA GTA AAT ATT CTG TCC CC-3' SspI ADH3 (351) 5'-AAT CTA CCT CTT TCC GAA GC-3' SspI Table 2.
The ADH2 genotype was determined by PCR and subsequent digestion with MaeIII, according to the method of Xu et al.
After amplification of the ADH2 allele, 2 [micro]L of the PCR products was used for the SSCP analysis, and 20 [micro]L of the PCR products was precipitated with ethanol.
In conclusion, (a) nucleic acids were successfully extracted from nail clippings by the present guanidine method, which was improved from the previous one that had succeeded DNA extraction even from manicured or smudgy nails without contamination due to using a nail clipper [12], (b) the ADH2 genotype was detected with complete specificity by the present method, and (c) nails may be a suitable material for DNA analysis with PCR in a population study, not least through ease in obtaining informed consent from the study subjects.
2) ADH1B and ADH1C were formerly called ADH2 and ADH3 respectively (for more information, see the accompanying article by Edenberg).
An earlier case-control study, conducted in Chinese patients, analyzed ADH2, ADH3, ALDH2, and CYP2E1 genes in patients with acute alcoholic pancreatitis, in alcoholic patients without organ damage, in patients with pancreatic disease of nonalcoholic origin, and in patients with alcoholic liver disease.
Further evidence comes from human epidemiological studies of FASD incidence and ADH2 polymorphism in a mixed-ancestry population in western Cape Town, South Africa.
Three different versions of ADH exist--ADH1, ADH2, and ADH3.
Newer studies have suggested that certain ADH2 and ADH3 alleles also protect carriers to some extent from developing alcoholism.
alcohol dehydrogenase) at two genes called ADH2 and ADH3 did not predict differences in alcohol reactivity, even though the ADH2*2 gene variant (i.
ADH2 gene polymorphism's are determinants of alcohol pharmacokinetics.