ADH1C

ADH1C

A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, gamma subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.
References in periodicals archive ?
ALDH2, ADH1B, and ADH1C genotypes in Asians: A literature review.
The study identified several SNPs in a region on chromosome 2 that previously had been linked to alcohol dependence, as well as SNPs in a gene called CDH13 that is located on chromosome 16 and the ADH gene ADH1C on chromosome 4.
Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population.
ADH1B enzymes that differ in the type of [beta] subunit are known as allelozymes, as are ADH1C enzymes that differ in the type of [gamma] subunit.
Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation.
Alterations in the ADH1C gene, which encodes the 7 subunit of alcohol dehydrogenase, can change alcohol metabolism by the encoded protein and have been associated with alcoholism, although these effects are not as pronounced as those noted with ADH1B*2 (Edenberg 2007).
One important group of ADH enzymes are the ADH class I isozymes ADH1A, ADH1B, and ADH1C.
For example, several studies found other variations in and near the ADH1B gene, as well as in or near the ADH4, ADH1C, ADH5, ADH6, and ADH7 genes that affect risk for alcoholism or the level of alcohol consumption (see the article by Hurley and Edenberg, pp.
For example, certain ADH1B and ADH1C alleles encode particularly active ADH enzymes, resulting in more rapid conversion of alcohol (i.
The ADH1A, ADH1B, and ADH1C genes (1) produce closely related proteins that function as homo- and heterodimers (Hurley et al.
There are three types of ADH1: ADH1A, ADH1B, and ADH1C.
The genes encoding the class I ADH enzymes are called ADH1A, ADH1B, and ADH1C.