ADH1C

ADH1C

A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, gamma subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.
References in periodicals archive ?
Around 80 percent of Asian people (less common in Thailand and India) have a variant of the gene coding for the enzyme alcohol dehydrogenase called ADH1B, whereas almost all Japanese, Chinese, and Korean people have a variant of the gene called ADH1C, both resulting in an alcohol dehydrogenase enzyme that converts alcohol to toxic acetaldehyde at a much higher efficiency than other gene variants from Caucasians.
In previous studies, marbling in TT type of ADH1C gene was higher than TC and CC type during the 5 months restriction of vitamin A in Angus crossbred steers [4].
Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Genome-wide association studies have identified numerous genes that contribute to drug abuse including CHRNA3-5 for nicotine dependence and ADH1B and ADH1C genes for alcohol dependence.
In exon 8 of the gene ADH1C is located allele wild ADH1C*1 (A) that codes for a protein subunit that position 350 has an isoleucine (ATT), the presence of a ADH1C*2 polymorphism known in which there is a change an A/G, leads to a substitution in the protein subunit isoleucine 350 by a valine (GTT).
The rates of metabolic pathways responsible for converting alcohol to acetaldehyde and acetaldehyde to acetate are mostly influenced by functional polymorphisms on ADH1B (previously called ADH2), ADH1C (previously called ADH3),andALDH2 [5-7].
The human ADH genes, ADH1B and ADH1C were found to have alleles that produce enzymes that catalyze the oxidation of ethanol to acetaldehyde.
The study identified several SNPs in a region on chromosome 2 that previously had been linked to alcohol dependence, as well as SNPs in a gene called CDH13 that is located on chromosome 16 and the ADH gene ADH1C on chromosome 4.
Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population.
ADH1B enzymes that differ in the type of [beta] subunit are known as allelozymes, as are ADH1C enzymes that differ in the type of [gamma] subunit.
A variant of the ADH1C gene, the ADH1 C*1 allele, also has been well studied with respect to alcohol dependence, but the results have been inconsistent because of limited sample sizes, ethnic variation, and the close proximity of the ADH 1B and ADH 1C genes.
One important group of ADH enzymes are the ADH class I isozymes ADH1A, ADH1B, and ADH1C.