ADH1B

ADH1B

A gene on chromosome 4q21-23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism.
References in periodicals archive ?
ey found that people who carried a certain genetic variant associated with non-drinking and lower alcohol consumption had a "more favourable cardiovascular pro'le" than those without the ADH1B variant.
ALDH2, ADH1B, and ADH1C genotypes in Asians: A literature review.
Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid.
ADH1B enzymes that differ in the type of [beta] subunit are known as allelozymes, as are ADH1C enzymes that differ in the type of [gamma] subunit.
For example, variants at the ADH1B locus that result in an altered amino acid sequence and function of the encoded enzyme can influence the severity of the adverse effects on the developing fetus (i.
Similar findings have been reported by others with the ADH1B pattern in other populations and studies (Jacobson et al.
Carriers of the variant genotype ADH1B were more likely to be abusers and had shorter telomere length, according to Baccarelli.
Some studies specifically have examined the ADH1B gene.
In the ADH1B gene, (1) a polymorphism called rs1229984 (also referred to as Arg48His), which differs from the normal, or wild-type, DNA sequence in a single nucleotide, results in an amino acid change at position 48 in the [beta] subunit of alcohol dehydrogenase from arginine to histidine (Edenberg 2007).
Another well-studied gene variant concerns the gene encoding the ADH1B enzyme.
Similarly, coding variations in the ADH1B gene (called ADH1B*2 and ADH1B*3) that encode highly active enzymes which increase the rate at which acetaldehyde is produced also are strongly protective and reduce the risk for alcohol dependence (Edenberg 2007; Thomasson et al.
The ADH1A, ADH1B, and ADH1C genes (1) produce closely related proteins that function as homo- and heterodimers (Hurley et al.