ADH1A

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ADH1A

A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, alpha subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.
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These primers were designed as mismatched 3'-end nucleotides of the ADH1 or ADH3 alleles for amplifying only the ADH2 allele.
Furthermore, polymorphisms exist for several of the genes encoding ADH enzymes, the best known of which occur in the genes encoding ADH1.
Increased liver ethanol metabolism in pregnant rats appeared not to be associated with changes in liver ADH1 activity (Badger et al.