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ADCC |
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ADCC antibody-dependent cell-mediated cytotoxicity. ADCC, abbreviation for antibody-dependent cell-mediated cytotoxicity. ADCC antibody-dependent cell-mediated cytotoxicity. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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It is based on an active modulation
of antibody glycosylation during production leading to antibody products
with increased ADCC (antibody-dependent cellular cytotoxicity). Two receptors found to predict ADCC activation and improved outcome
to rituximab,(2,3) known as Fc(gamma)RIIIa 158V/F and Fc(gamma)RIIa 131
H/R, were also found to be potential molecular markers for ADCC
activation and improved clinical outcome of patients treated with single
agent ERBITUX. Pre-clinical data presented on ERBITUX, an IgG1 monoclonal antibody
(MAb), included a study examining the IgG1 MAb-mediated anti-tumor
effects known as ADCC (antibody-dependent cell-mediated cytotoxicity),
or the recruitment of the body's immune defenses to attack cancer
cells. |
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